Huang Weichao, Ma Xiaoman, Chen Yue, Zheng Jiayi, Li Haojia, Nizhamu Ayinigaer, Hong Qingting, Guo Xuguang
Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Clinical Medicine, The Second Clinical School of Guangzhou Medical University, Guangzhou, China.
Front Nutr. 2022 Feb 24;9:829857. doi: 10.3389/fnut.2022.829857. eCollection 2022.
Although the association between blood pressure and vitamin D has been well studied, the effects of dietary magnesium intake on this relationship are still unclear. Thus, this study aimed to determine the effects of dietary magnesium intake on the association between vitamin D and blood pressure.
The present study analyzed data from the continuous the National Health and Nutrition Examination Survey (NHANES) 2007-2014. We included 8,799 participants aged 20 years or older. Multivariable linear regression was performed to assess the association between vitamin D and systolic blood pressure (SBP) and diastolic blood pressure (DBP). Dietary magnesium intake was stratified by low magnesium intake (<299 mg/d) and high magnesium intake (≥299 mg/d). Effect modification by dietary magnesium intake was assessed through interaction tests between vitamin D and SBP in the multivariable linear regression.
In this cross-sectional study, we found that vitamin D was negatively related to SBP, but not to DBP. The relationship between vitamin D and SBP was different in the low and high magnesium intake group (β: -0.25 95%Cl: -0.40.07 vs β: -0.32 95%Cl: -0.52-0.12). Furthermore, magnesium intake significantly modified the negative relationship between vitamin D and SBP in most of the models.
Our research showed that magnesium and vitamin D have an interactive effect in reducing SBP, which may have great importance for clinical medication.
尽管血压与维生素D之间的关联已得到充分研究，但膳食镁摄入量对这种关系的影响仍不明确。因此，本研究旨在确定膳食镁摄入量对维生素D与血压之间关联的影响。
本研究分析了2007 - 2014年美国国家健康与营养检查调查（NHANES）连续性数据。我们纳入了8799名20岁及以上的参与者。采用多变量线性回归来评估维生素D与收缩压（SBP）和舒张压（DBP）之间的关联。膳食镁摄入量根据低镁摄入量（<299毫克/天）和高镁摄入量（≥299毫克/天）进行分层。通过多变量线性回归中维生素D与SBP之间的交互作用检验来评估膳食镁摄入量的效应修正。
在这项横断面研究中，我们发现维生素D与SBP呈负相关，但与DBP无关。低镁摄入量组和高镁摄入量组中维生素D与SBP之间的关系不同（β：-0.25 95%置信区间：-0.40.07 对比 β：-0.32 95%置信区间：-0.52-0.12）。此外，在大多数模型中，镁摄入量显著修正了维生素D与SBP之间的负相关关系。
我们的研究表明，镁和维生素D在降低SBP方面具有交互作用，这可能对临床用药具有重要意义。
