McComb J M, Logan K R, Khan M M, Geddes J S, Adgey A A
Eur J Cardiol. 1980;11(5):381-5.
Amiodarone, 600 mg orally daily, was used in an attempt to control supraventricular tachyarrhythmias in a patient with the sick sinus syndrome. Twenty days from the onset of therapy the Q-T interval lengthened. Episodes of ventricular flutter, ventricular fibrillation and self-terminating ventricular tachyarrhythmia (torsade de pointes) developed on the 28th day of amiodarone therapy. Temporary cardiac pacing prevented further episodes of ventricular fibrillation. Despite the suggestion that this drug may be given in large doses for long periods of time since it has a wide safety margin, we feel that the risk of lethal arrhythmias is such that caution is required in its use.
一名患有病态窦房结综合征的患者口服胺碘酮，每日600毫克，试图控制室上性快速心律失常。治疗开始20天后，Q-T间期延长。在胺碘酮治疗的第28天出现了室性扑动、室性颤动和自行终止的室性快速心律失常（尖端扭转型室速）。临时心脏起搏预防了室颤的进一步发作。尽管有观点认为该药安全范围广，可大剂量长期使用，但我们认为致死性心律失常的风险使得在使用时需要谨慎。
