Hoover C I, Newbrun E, Mettraux G, Graf H
Infect Immun. 1980 Jun;28(3):853-9. doi: 10.1128/iai.28.3.853-859.1980.
We compared the microbiological and chemical composition of dental plaque from subjects with hereditary fructose intolerance who restrict their dietary sugar intake with that of control subjects who do not. The two groups showed no significant differences in chemical composition of plaque: the mean protein, carbohydrate, calcium, magnesium, and phosphate contents were similar. Dental plaque from both groups contained similar numbers of total colony-forming units per microgram of plaque protein, and Streptococcus sanguis, an indigenous nonpathogen, was isolated with equal frequency from plaque samples of both groups. However, potentially odontopathic Streptococcus mutans and Lactobacillus were isolated three to four times more frequently from plaque samples of control subjects than from plaque samples of subjects with hereditary fructose intolerance. Clearly, diet (sucrose in particular) influences the colonization and multiplication of specific cariogenic organisms in dental plaque.
我们比较了限制饮食中糖摄入量的遗传性果糖不耐受受试者与不限制的对照受试者牙菌斑的微生物学和化学组成。两组菌斑的化学成分无显著差异：蛋白质、碳水化合物、钙、镁和磷酸盐的平均含量相似。两组牙菌斑每微克菌斑蛋白中所含的总菌落形成单位数量相似，并且从两组的菌斑样本中以相同频率分离出一种本地非病原体——血链球菌。然而，从对照受试者的菌斑样本中分离出潜在致龋的变形链球菌和乳酸杆菌的频率比从遗传性果糖不耐受受试者的菌斑样本中高出三到四倍。显然，饮食（尤其是蔗糖）会影响牙菌斑中特定致龋生物的定植和繁殖。
