信使核糖核酸浓度对帽类似物翻译竞争性抑制的影响。
The effect of the messenger RNA concentration on the competitive inhibition of translation by cap-analogues.
作者信息
Asselbergs F A, Peters W H, van Venrooij W J, Bloemendal H
出版信息
Mol Biol Rep. 1978 Oct 16;4(3):177-80. doi: 10.1007/BF00777520.
Inhibition of translation of several mRNA species in a micrococcal nuclease treated reticulocyte lysate by cap analogues was compared with the competition between two mRNAs. Inhibition characteristics were very similar, only complete mRNA molecules inhibited at concentrations 150 times lower than m7 G5'ppp5'G. The inhibition of mRNA translation by cap analogues could be neutralized by the addition of extra mRNA in a manner predicted from the competitive nature of the inhibition by cap analogues.
将帽类似物对微球菌核酸酶处理的网织红细胞裂解物中几种mRNA种类翻译的抑制作用与两种mRNA之间的竞争进行了比较。抑制特性非常相似，只有完整的mRNA分子在比m7G5'ppp5'G低150倍的浓度下被抑制。帽类似物对mRNA翻译的抑制作用可以通过添加额外的mRNA以帽类似物抑制的竞争性质所预测的方式来中和。
Zotero 插件