Schlesinger Z, Barzilay J
Isr J Med Sci. 1980 Jun;16(6):420-5.
The effects of oxprenolol on blood pressure levels, pulmonary ventilatory function, myocardial contractility and myocardial oxygen consumption are described in 66 patients with essential hypertension and no clinical evidence of obstructive lung disease of heart failure. Two groups of patients were treated with medication for a total of 16 weeks. Group 1 received oxprenolol and diuretics for the first eight weeks and a placebo plus diuretics for the second eight weeks. Group 2 received the same drugs in reverse order. The results of the study indicate that oxprenolol is an effective antihypertensive drug that does not hamper lung volume capacity or myocardial contractility and markedly reduces myocardial oxygen consumption, although it may cause a mild increase in airway resistance.
在66例原发性高血压且无阻塞性肺病或心力衰竭临床证据的患者中，描述了氧烯洛尔对血压水平、肺通气功能、心肌收缩力和心肌耗氧量的影响。两组患者接受药物治疗共16周。第一组在前八周接受氧烯洛尔和利尿剂治疗，后八周接受安慰剂加利尿剂治疗。第二组则顺序相反地接受相同药物治疗。研究结果表明，氧烯洛尔是一种有效的抗高血压药物，它不会妨碍肺容量或心肌收缩力，并且能显著降低心肌耗氧量，尽管它可能会导致气道阻力轻度增加。
