Habal M B, Powell R D
J Biomed Mater Res. 1980 Jul;14(4):447-54. doi: 10.1002/jbm.820140411.
An evaluation of the biophysical changes of methylcholanthrene induced tumor (M4) in laboratory animals receiving four different alloplastic implants was conducted. The implants are silicone, polyether urethane, poly(methyl methacrylate), and bioglass. The tumor was allowed to grow to a large size in 28 days and then removed by shelling it from the surrounding tissue. Three different analytic volumetric measurements were carried; size in cm3, volume in milliliters and weight in grams. Statistical analysis on the three different analytic measurements did not disclose any significant differences in tumor growth potential between the control and the experimental groups. We conclude that in this study we were unable to demonstrate any tumor "facilitation" effect by any of the implantable polymers used. Therefore, there is no contraindication in using the polymers to reconstruct defects produced by cancer ablative procedures.
对接受四种不同异体植入物的实验动物中甲基胆蒽诱导肿瘤（M4）的生物物理变化进行了评估。这些植入物分别是硅酮、聚醚聚氨酯、聚甲基丙烯酸甲酯和生物玻璃。让肿瘤在28天内生长到较大尺寸，然后通过从周围组织中剥离将其切除。进行了三种不同的分析体积测量；以立方厘米为单位的尺寸、以毫升为单位的体积和以克为单位的重量。对这三种不同分析测量的统计分析未显示对照组和实验组之间肿瘤生长潜力有任何显著差异。我们得出结论，在本研究中，我们无法证明所使用的任何可植入聚合物有任何肿瘤“促进”作用。因此，在使用这些聚合物重建癌症消融手术产生的缺损方面没有禁忌证。
