中性粒细胞在牛流行热病毒感染牛中的作用。
The role of neutrophils in bovine ephemeral fever virus infection of cattle.
作者信息
Young P L, Spradbrow P B
出版信息
J Infect Dis. 1980 Jul;142(1):50-5. doi: 10.1093/infdis/142.1.50.
Bovine ephemeral fever is a rhabdoviral disease characterized by a pronounced neutrophilia and an influx of neutrophils into serosae and serosal fluids. Studies were undertaken on the effect of bovine ephemeral fever virus infection of cattle with an induced neutropenia. An equine antiserum to bovine neutrophils was produced using neutrophils derived from a bovine udder. This antiserum was used to deplete circulating neutrophils in three calves that were infected with virulent bovine ephemeral fever virus. The calves became viremic without developing clinical signs and without developing detectable antibodies to bovine ephemeral fever virus. Three months later, after restoration of blood neutrophil levels to normal values, two of these calves were again infected with virulent bovine ephemeral fever virus. Both calves developed viremia, clinical disease, and serum-neutralizing antibodies to bovine ephemeral fever virus.
牛暂时热是一种弹状病毒病，其特征是明显的嗜中性粒细胞增多以及嗜中性粒细胞流入浆膜和浆膜液。对患有诱导性中性粒细胞减少症的牛感染牛暂时热病毒的影响进行了研究。使用源自牛乳房的嗜中性粒细胞制备了抗牛嗜中性粒细胞的马抗血清。该抗血清用于消耗三只感染强毒牛暂时热病毒的犊牛体内循环的嗜中性粒细胞。犊牛出现病毒血症，但未出现临床症状，也未产生可检测到的抗牛暂时热病毒抗体。三个月后，在血液嗜中性粒细胞水平恢复到正常值后，其中两只犊牛再次感染强毒牛暂时热病毒。两只犊牛均出现病毒血症、临床疾病以及抗牛暂时热病毒的血清中和抗体。
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