Fraschini F, Ferioli M E, Nebuloni R, Scalabrino G
J Neural Transm. 1980;48(3):209-21. doi: 10.1007/BF01243505.
The activity of ornithine decarboxylase was assayed in several organs (thymus, testes, prostate gland, liver, kidneys, adenohypophysis, anterior hypothalamus, and adrenals) taken from adult male rats killed at seven day interval up to six weeks after pinealectomy. The absence of the pineal gland particularly influences the ornithine decarboxylase activity in the thymus, in which the level of the enzyme is decreased irreversibly by the fourth week after the operation. In other organs the ornithine decarboxylase activity was often significantly different from that of corresponding shampinealectomized controls at various weeks after the surgical removal of the gland. Moreover, these differences between operated and sham-operated animals are sometimes positive, sometimes negative. Thus, the polyamine biosynthetic pathway in different organs appears to be regulated, directly or indirectly, by a new neuroendocrine centre, the pineal gland, and this pineal gland has thus been shown to be active in adult life in correlating endocrine-enzymatic functions.
对成年雄性大鼠松果体切除术后，每隔七天处死一批大鼠，直至术后六周，取其多个器官（胸腺、睾丸、前列腺、肝脏、肾脏、腺垂体、下丘脑前部和肾上腺）测定鸟氨酸脱羧酶的活性。松果体缺失尤其影响胸腺中的鸟氨酸脱羧酶活性，术后第四周时该酶水平不可逆降低。在其他器官中，手术切除腺体后的不同周数，鸟氨酸脱羧酶活性常与相应的假手术对照组有显著差异。此外，手术组和假手术组动物之间的这些差异有时为正，有时为负。因此，不同器官中的多胺生物合成途径似乎直接或间接受一个新的神经内分泌中心——松果体的调节，并且已证明该松果体在成年期对内分泌-酶功能的关联中具有活性。
