大鼠前列腺中腐胺的生物合成
Biosynthesis of putrescine in the prostate gland of the rat.
作者信息
Pegg A E, Williams-Ashman H G
出版信息
Biochem J. 1968 Jul;108(4):533-9. doi: 10.1042/bj1080533.
Abstract
In the rat ventral prostate gland the biosynthesis of putrescine, a precursor of spermidine and spermine, is shown to occur by the direct decarboxylation of l-ornithine. Some properties of a soluble pyridoxal phosphate-dependent l-ornithine decarboxylase are described. The findings are discussed in relation to other enzymic reactions involved in the biosynthesis of polyamines by the prostate gland.
摘要
在大鼠腹侧前列腺中，腐胺（精胺和亚精胺的前体）的生物合成显示是通过L-鸟氨酸的直接脱羧作用进行的。本文描述了一种可溶性磷酸吡哆醛依赖性L-鸟氨酸脱羧酶的一些特性。结合前列腺中多胺生物合成所涉及的其他酶促反应对这些发现进行了讨论。
相似文献
1
Biosynthesis of putrescine in the prostate gland of the rat.大鼠前列腺中腐胺的生物合成
Biochem J. 1968 Jul;108(4):533-9. doi: 10.1042/bj1080533.
2
Concentrations of putrescine and polyamines and their enzymic synthesis during androgen-induced prostatic growth.雄激素诱导前列腺生长过程中腐胺和多胺的浓度及其酶促合成
Biochem J. 1970 Mar;117(1):17-31. doi: 10.1042/bj1170017.
3
4
Biosynthesis of putrescine: characterization of ornithine decarboxylase from regenerating rat liver.腐胺的生物合成：再生大鼠肝脏中鸟氨酸脱羧酶的特性
Acta Chem Scand. 1968;22(7):2375-8. doi: 10.3891/acta.chem.scand.22-2375.
5
Polyamine biosynthesis and vitamin B6 deficiency. Evidence for pyridoxal phosphate as coenzyme for S-adenosylmethionine decarboxylase.多胺生物合成与维生素B6缺乏症。磷酸吡哆醛作为S-腺苷甲硫氨酸脱羧酶辅酶的证据。
Biochim Biophys Acta. 1974 Nov 4;372(1):162-70. doi: 10.1016/0304-4165(74)90083-x.
6
Inhibitors of polyamine biosynthesis. 3. (+/-)-5-Amino-2-hydrazine-2-methylpentanoic acid, an inhibitor of ornithine decarboxylase.多胺生物合成抑制剂。3. （±）-5-氨基-2-肼基-2-甲基戊酸，一种鸟氨酸脱羧酶抑制剂。
J Med Chem. 1975 Sep;18(9):945-8. doi: 10.1021/jm00243a017.
7
The regulation of mouse liver ornithine decarboxylase by metabolites.代谢物对小鼠肝脏鸟氨酸脱羧酶的调节作用。
Biochim Biophys Acta. 1976 Jul 8;438(2):551-62. doi: 10.1016/0005-2744(76)90271-0.
8
Adenosylmethionine decarboxylase in developing rat brain.发育中大鼠脑内的腺苷甲硫氨酸脱羧酶
J Neurochem. 1973 May;20(5):1373-85. doi: 10.1111/j.1471-4159.1973.tb00249.x.
9
S-adenosylmethionine decarboxylase from human prostate. Activation by putrescine.来自人前列腺的S-腺苷甲硫氨酸脱羧酶。腐胺对其的激活作用。
Biochem J. 1972 Sep;129(3):703-9. doi: 10.1042/bj1290703.
10
Inhibitors of polyamine biosynthesis. 1. Alpha-methyl-(plus or minus)-ornithine, an inhibitor of ornithine decarboxylase.多胺生物合成抑制剂。1. α-甲基-（±）-鸟氨酸，一种鸟氨酸脱羧酶抑制剂。
J Med Chem. 1974 Apr;17(4):447-51. doi: 10.1021/jm00250a016.
引用本文的文献
1
DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.DDR2 调控卵巢癌相关成纤维细胞中的精氨酸酶活性促进胶原产生和肿瘤进展。
Oncogene. 2024 Jan;43(3):189-201. doi: 10.1038/s41388-023-02884-3. Epub 2023 Nov 23.
2
Arginine Supplementation Promotes Extracellular Matrix and Metabolic Changes in Keratoconus.精氨酸补充促进圆锥角膜细胞外基质和代谢变化。
Cells. 2021 Aug 13;10(8):2076. doi: 10.3390/cells10082076.
3
Ornithine Decarboxylase Activity Is Required for Prostatic Budding in the Developing Mouse Prostate.鸟氨酸脱羧酶活性是发育中小鼠前列腺前列腺芽形成所必需的。
PLoS One. 2015 Oct 1;10(10):e0139522. doi: 10.1371/journal.pone.0139522. eCollection 2015.
4
Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy.睾酮联合鸟氨酸脱羧酶抑制剂作为一种选择性保留前列腺的合成代谢疗法。
Aging Cell. 2014 Apr;13(2):303-10. doi: 10.1111/acel.12174. Epub 2013 Dec 4.
5
A novel gene signature for molecular diagnosis of human prostate cancer by RT-qPCR.一种通过逆转录定量聚合酶链反应进行人类前列腺癌分子诊断的新型基因特征。
PLoS One. 2008;3(10):e3617. doi: 10.1371/journal.pone.0003617. Epub 2008 Oct 31.
6
Polyamines in type 5 adenovirus-infected cells and virions.5型腺病毒感染细胞和病毒粒子中的多胺
J Virol. 1975 May;15(5):1289-92. doi: 10.1128/JVI.15.5.1289-1292.1975.
7
Putrescine biosynthesis in mammalian tissues.哺乳动物组织中的腐胺生物合成。
Biochem J. 2004 May 1;379(Pt 3):849-55. doi: 10.1042/BJ20040035.
8
Maturation of villus and crypt cell functions in rat small intestine. Role of dietary polyamines.大鼠小肠绒毛和隐窝细胞功能的成熟。膳食多胺的作用。
Dig Dis Sci. 1993 Jun;38(6):1091-8. doi: 10.1007/BF01295726.
9
Pineal gland and polyamines.松果体与多胺
J Neural Transm. 1980;48(3):209-21. doi: 10.1007/BF01243505.
10
Studies on sex organ development. Effect of hormones on ornithine decarboxylase activity in the developing chick ovary.性器官发育研究。激素对发育中的雏鸡卵巢中鸟氨酸脱羧酶活性的影响。
Biochem J. 1980 May 15;188(2):313-9. doi: 10.1042/bj1880313.
本文引用的文献
1
Spermidine in Regenerating Liver: Relation to Rapid Synthesis of Ribonucleic Acid.精胺在肝脏再生中的作用：与核糖核酸的快速合成有关。
Science. 1965 Jul 23;149(3682):428-9. doi: 10.1126/science.149.3682.428.
2
Polyamines and nucleic acids during development of the chick embryo.鸡胚发育过程中的多胺与核酸
Biochem J. 1965 Oct;97(1):84-8. doi: 10.1042/bj0970084.
3
The production of amines by bacteria: The decarboxylation of amino-acids by strains of Bacterium coli.细菌产生胺类物质：大肠杆菌菌株对氨基酸的脱羧作用。
Biochem J. 1940 Mar;34(3):392-413. doi: 10.1042/bj0340392.
4
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
5
Glutamic acid decarboxylase. III. The inactivation of the enzyme at low temperatures.谷氨酸脱羧酶。III. 该酶在低温下的失活
J Biol Chem. 1960 Jun;235:1658-61.
6
INHIBITION OF HISTAMINE SYNTHESIS IN THE RAT BY ALPHA-HYDRAZINO ANALOG OF HISTIDINE AND 4-BROMO-3-HYDROXY BENZYLOXYAMINE.组氨酸的α-肼基类似物和4-溴-3-羟基苄氧基胺对大鼠组胺合成的抑制作用
Biochem Pharmacol. 1965 Feb;14:139-49. doi: 10.1016/0006-2952(65)90069-9.
7
SPERMIDINE, SPERMINE, AND RELATED AMINES.亚精胺、精胺及相关胺类
Pharmacol Rev. 1964 Sep;16:245-300.
8
OBSERVATIONS ON POLYAMINES IN MALE ACCESSORY GLANDS OF REPRODUCTION.雄性生殖附属腺中多胺的观察
Med Exp Int J Exp Med. 1964;10:281-5. doi: 10.1159/000135428.
9
The biosynthesis of spermidine and spermine from putrescine and methionine.由腐胺和蛋氨酸生物合成亚精胺和精胺。
J Biol Chem. 1958 Oct;233(4):907-14.
10
The separation of aliphatic amines by paper chromatography or paper electrophoresis.通过纸色谱法或纸电泳法分离脂肪胺。
Arch Biochem Biophys. 1958 May;75(1):178-85. doi: 10.1016/0003-9861(58)90408-9.
Zotero 插件