Vieras F, Barron E L, Parker G A, Grissom M P
J Nucl Med. 1980 Aug;21(8):723-8.
Based on literature reports suggesting the possible incorporation of Tc-99m sulfur colloid (Tc-SC) into fibrin deposits, this study was undertaken to evaluate the potential of this radiopharmaceutical as an imaging agent in thromboembolic disease. Animal models of deep-vein thrombosis and pulmonary embolism were used. The mean thrombus-to-blood (T/B) uptake ratios were comparable for fresh and older thrombi (up to 72 hr). Thrombus uptake was significantly lower in a group of five control dogs that received pertechnetate instead of Tc-SC. Intravenous heparin administration (5,000 IU) 2 hr before injection of Tc-SC caused a depression in T/B ratios but did not totally block Tc-SC uptake. Gamma imaging with Tc-SC allowed demonstration of deep-vein thrombi, but imaging of pulmonary emboli as areas of increased activity was not satisfactory. This study supports the concept of thrombus detection with radiolabeled particles but not the extension of this principle to the imaging of pulmonary emboli.
基于文献报道提示99m锝硫胶体（Tc-SC）可能掺入纤维蛋白沉积物中，开展本研究以评估这种放射性药物作为血栓栓塞性疾病显像剂的潜力。使用了深静脉血栓形成和肺栓塞的动物模型。新鲜血栓和陈旧血栓（长达72小时）的平均血栓与血液（T/B）摄取率相当。在一组接受高锝酸盐而非Tc-SC的5只对照犬中，血栓摄取明显较低。注射Tc-SC前2小时静脉注射肝素（5000 IU）导致T/B比值降低，但并未完全阻断Tc-SC摄取。用Tc-SC进行γ显像可显示深静脉血栓，但将肺栓塞显像为活性增加区域并不理想。本研究支持用放射性标记颗粒检测血栓的概念，但不支持将该原理扩展至肺栓塞显像。
