氯霉素、氯霉素-3-单琥珀酸酯和氯霉素-1-单琥珀酸酯的高压液相色谱测定法。
High-pressure liquid chromatographic assay for chloramphenicol, chloramphenicol-3-monosuccinate, and chloramphenicol-1-monosuccinate.
作者信息
Burke J T, Wargin W A, Blum M R
出版信息
J Pharm Sci. 1980 Aug;69(8):909-12. doi: 10.1002/jps.2600690813.
PMID:7400935
Abstract
A high-pressure liquid chromatographic method for the sensitive and rapid determination of chloramphenicol, chloramphenicol-3-monosuccinate, and chloramphenicol-1-monosuccinate is presented. The procedure utilizes a reversed-phase chromatographic column with UV absorption detection. The assay is useful for monitoring patients receiving chloramphenicol, determining the pharmacokinetics of parenteral chloramphenicol sodium succinate, and certifying sterile chloramphenicol sodium succinate.
摘要
本文介绍了一种用于灵敏、快速测定氯霉素、氯霉素-3-单琥珀酸酯和氯霉素-1-单琥珀酸酯的高压液相色谱法。该方法采用反相色谱柱和紫外吸收检测。该测定法可用于监测接受氯霉素治疗的患者、确定静脉注射琥珀氯霉素的药代动力学以及鉴定琥珀氯霉素无菌制剂。
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引用本文的文献
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Pharmacokinetics of intravenous chloramphenicol sodium succinate in adult patients with normal renal and hepatic function.
J Pharmacokinet Biopharm. 1982 Dec;10(6):601-14. doi: 10.1007/BF01062543.
2
Analysis of the mechanism of chloramphenicol acetyltransferase by steady-state kinetics. Evidence for a ternary-complex mechanism.
Biochem J. 1984 Oct 1;223(1):211-20. doi: 10.1042/bj2230211.
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Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate.
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