氯霉素-3-单琥珀酸酯的重排
Rearrangement of chloramphenicol-3-monosuccinate.
作者信息
Brent D A, Chandrasurin P, Ragouzeos A, Hurlbert B S, Burke J T
出版信息
J Pharm Sci. 1980 Aug;69(8):906-8. doi: 10.1002/jps.2600690812.
PMID:6249906
Abstract
The equilibrium mixture of chloramphenicol-3-monosuccinate and its alternate form at neutral pH in aqueous solution was reexamined. The structure of the alternate form was shown by mass specxtrometry and NMR spectroscopy to be chloramphenicol-1-monosuccinate and not the cyclic hemi-ortho ester reported previously.
摘要
重新研究了氯霉素-3-单琥珀酸酯及其替代形式在中性pH值水溶液中的平衡混合物。通过质谱和核磁共振光谱表明，替代形式的结构为氯霉素-1-单琥珀酸酯，而非先前报道的环状半原酸酯。
Zotero 插件