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Effect of sodium bicarbonate on in vitro conversion of fibrinogen to fibrin.

作者信息

Wong D W

出版信息

J Pharm Sci. 1980 Aug;69(8):978-80. doi: 10.1002/jps.2600690832.

DOI:10.1002/jps.2600690832
PMID:7400952
Abstract

The effect of sodium bicarbonate on the conversion of fibrinogen to fibrin clot was investigated using fresh human whole blood and pure human fibrinogen. In vitro experimental data demonstrated that sodium bicarbonate interfered with fibrin clot formation during clotting. This study assessed the possibility of synergistic action of sodium bicarbonate with dosium citrate. As expected, sodium citrate potentiated the anticoagulant action of sodium bicarbonate.

摘要

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