Wong D W, Mishkin F S, Tanaka T T
JAMA. 1980 Jul 4;244(1):61-2.
The anticoagulant effects of sodium and potassium bicarbonate were investigated with use of fresh human whole blood obtained from normal healthy volunteers. Results from prothrombin and thrombin clotting time determinations demonstrated that bicarbonate can interfere with the clotting process. Clinical data obtained from patients who received intravenous administration of sodium bicarbonate supported these findings.
利用从正常健康志愿者采集的新鲜人体全血，研究了碳酸氢钠和碳酸氢钾的抗凝作用。凝血酶原和凝血酶凝血时间测定结果表明，碳酸氢盐可干扰凝血过程。从接受静脉注射碳酸氢钠的患者获得的临床数据支持了这些发现。
