Arendsen de Wolff-Exalto E, Groen-Klevant A C
J Reprod Fertil. 1980 May;59(1):187-92. doi: 10.1530/jrf.0.0590187.
Growth rates of oocytes in the ovary cannot be measured directly. However, oocyte growth can be determined by relating oocyte diameter to the time the enclosing follicle has been growing, calculated from kinetic studies of granulosa cell doubling time. For the ovaries of immature rats aged 16 and 28 days, oocyte diameter platted against time gave straight and parallel lines, showing that the diameter is positively and linearly related to time and that oocytes grow at the same rate at both ages. However, during earliest developmental stages (type 3a follicles with 10-20 granulosa cells) the growth rates differed, being faster at 16 days and slower at 28 days than at later stages.
卵巢中卵母细胞的生长速率无法直接测量。然而，卵母细胞的生长可以通过将卵母细胞直径与包围它的卵泡的生长时间相关联来确定，这一时间是根据颗粒细胞倍增时间的动力学研究计算得出的。对于16日龄和28日龄未成熟大鼠的卵巢，将卵母细胞直径与时间作图得到直线且相互平行，表明直径与时间呈正线性相关，且两个年龄段的卵母细胞生长速率相同。然而，在最早的发育阶段（含有10 - 20个颗粒细胞的3a型卵泡），生长速率有所不同，16日龄时比后期更快，28日龄时比后期更慢。
