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促性腺激素对未成熟大鼠早期卵泡细胞发育和早期卵母细胞生长的影响。

Influence of gonadotrophins on early follicle cell development and early oocyte growth in the immature rat.

作者信息

Arendsen de Wolff-Exalto E

出版信息

J Reprod Fertil. 1982 Nov;66(2):537-42. doi: 10.1530/jrf.0.0660537.

DOI:10.1530/jrf.0.0660537
PMID:6816928
Abstract

Ovaries of neonatal rats were transplanted on the day after birth into ovariectomized (high gonadotrophin levels) or ovariectomized-hypophysectomized adult female rats (extremely low gonadotrophin levels). Although transplantation caused a reduction of the number of growing follicles in all transplants, it did not seem to induce a clearly abnormal course of follicle development. After 15 days of development, the hormone-rich transplants contained a greater number of follicles larger than type 4 and a smaller number of oocytes with diameters less than 21 micrometers, than did the hormone-poor transplants. In the transplants with high hormone levels, the smallest follicles (types 2--3a) showed advanced transition of flattened into cuboidal follicle cells and oocyte growth. It is concluded that in these experimental conditions gonadotrophins, presumably especially FSH, seem to have a stimulatory effect on early follicle cell development and early oocyte growth.

摘要

新生大鼠的卵巢在出生后第二天被移植到切除卵巢的(促性腺激素水平高)成年雌性大鼠或切除卵巢并垂体切除的成年雌性大鼠(促性腺激素水平极低)体内。尽管移植导致所有移植卵巢中生长卵泡数量减少,但似乎并未诱导卵泡发育出现明显异常过程。发育15天后,与激素含量低的移植卵巢相比,激素含量高的移植卵巢含有更多大于4型的卵泡以及更少直径小于21微米的卵母细胞。在激素水平高的移植卵巢中,最小的卵泡(2 - 3a型)显示扁平卵泡细胞向立方卵泡细胞的高级转变以及卵母细胞生长。得出的结论是,在这些实验条件下,促性腺激素,大概尤其是促卵泡激素,似乎对早期卵泡细胞发育和早期卵母细胞生长具有刺激作用。

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