Arendsen de Wolff-Exalto E
J Reprod Fertil. 1982 Nov;66(2):537-42. doi: 10.1530/jrf.0.0660537.
Ovaries of neonatal rats were transplanted on the day after birth into ovariectomized (high gonadotrophin levels) or ovariectomized-hypophysectomized adult female rats (extremely low gonadotrophin levels). Although transplantation caused a reduction of the number of growing follicles in all transplants, it did not seem to induce a clearly abnormal course of follicle development. After 15 days of development, the hormone-rich transplants contained a greater number of follicles larger than type 4 and a smaller number of oocytes with diameters less than 21 micrometers, than did the hormone-poor transplants. In the transplants with high hormone levels, the smallest follicles (types 2--3a) showed advanced transition of flattened into cuboidal follicle cells and oocyte growth. It is concluded that in these experimental conditions gonadotrophins, presumably especially FSH, seem to have a stimulatory effect on early follicle cell development and early oocyte growth.
新生大鼠的卵巢在出生后第二天被移植到切除卵巢的(促性腺激素水平高)成年雌性大鼠或切除卵巢并垂体切除的成年雌性大鼠(促性腺激素水平极低)体内。尽管移植导致所有移植卵巢中生长卵泡数量减少,但似乎并未诱导卵泡发育出现明显异常过程。发育15天后,与激素含量低的移植卵巢相比,激素含量高的移植卵巢含有更多大于4型的卵泡以及更少直径小于21微米的卵母细胞。在激素水平高的移植卵巢中,最小的卵泡(2 - 3a型)显示扁平卵泡细胞向立方卵泡细胞的高级转变以及卵母细胞生长。得出的结论是,在这些实验条件下,促性腺激素,大概尤其是促卵泡激素,似乎对早期卵泡细胞发育和早期卵母细胞生长具有刺激作用。