Sessa A, Cioffi A, Conte F, Saruggia M, Di Belgiojoso G B, Donati M B
Nephron. 1978;22(4-6):439-53. doi: 10.1159/000181512.
The effects of indomethacin and lysine acetylsalicylate (L-ASA) were compared in rats in which autologous nephrotoxic serum nephritis had been induced. The aim of this study was to offer support to the hypothesis that indomethacin might reduce proteinuria through increased synthesis of glomerular basement membrane by the podocytes. Both drugs were injected intraperitoneally at the dosage of 4 mg/kg body weight daily during a 6-day period into 40 rats rendered nephritic by rabbit nephrotoxic serum injection. Rats treated with indomethacin showed a marked decrease of proteinuria (tested by the 3% sulfosalicylic aicd method) and a clear ultrastructural picture of hyperplasia and hypertrophy of podocytes. Rats given L-ASA showed only a slight correction of proteinuria and less specific ultrastructural modification. These observations suggest that indomethacin decreases proteinuria in nephritic rats not only through its anti-inflammatory activity, but possible also by a peculiar mechanism, namely an increase in podocytic basement membrane synthesis.
在诱导了自体肾毒性血清肾炎的大鼠中比较了吲哚美辛和赖氨酸乙酰水杨酸（L-ASA）的作用。本研究的目的是支持以下假设：吲哚美辛可能通过足细胞增加肾小球基底膜的合成来减少蛋白尿。在6天的时间里，每天以4mg/kg体重的剂量将两种药物腹腔注射到40只通过注射兔肾毒性血清而患肾炎的大鼠中。用吲哚美辛治疗的大鼠蛋白尿明显减少（通过3%磺基水杨酸法检测），并且足细胞增生和肥大的超微结构图像清晰。给予L-ASA的大鼠仅蛋白尿略有改善，超微结构改变特异性较小。这些观察结果表明，吲哚美辛降低肾炎大鼠的蛋白尿不仅通过其抗炎活性，还可能通过一种特殊机制，即足细胞基底膜合成增加。
