Kurokawa H, Sakamoto K
Br J Pharmacol. 1982 Jan;75(1):87-92. doi: 10.1111/j.1476-5381.1982.tb08760.x.
1 The effects of aspirin, prednisolone, and indomethacin on nephrotoxic serum nephritis in rats was studied. The nephritis was induced by a single intravenous injection of nephrotoxic serum (NTS, rabbit anti-serum against the water-soluble renal antigen of the rat). The injection of NTS induced the heterologous phase of proteinuria (within a day after NTS injection) and then the autologous phase (5 to 7 days after NTS injection). The effect of drugs given before the NTS (i.e. prophylactically) or after the NTS (i.e. therapeutically) was investigated. 2 Aspirin, which was given orally at doses of 150 and 250 mg/kg daily from the day before NTS injection, suppressed the development of proteinuria in both the heterologous and the autologous phase, and lowered the serum cholesterol level towards the normal level. Aspirin (250 mg/kg daily, orally) had no significant effect against the established proteinuria in the autologous phase. 3 Prednisolone, which was given orally at doses of 3 and 5 mg/kg daily from the day before NTS injection, elevated the proteinuria in the heterologous phase, while inhibiting the development of proteinuria in the autologous phase. Prednisolone (5 mg/kg daily, orally) was ineffective against established proteinuria in the autologous phase. 5 Indomethacin (3 mg/kg daily, orally) did not exert any significant effect on proteinuria in either the heterologous or the autologous phase.
1 研究了阿司匹林、泼尼松龙和吲哚美辛对大鼠肾毒性血清性肾炎的影响。通过单次静脉注射肾毒性血清（NTS，兔抗大鼠水溶性肾抗原血清）诱导肾炎。注射NTS诱导蛋白尿的异源期（NTS注射后一天内），然后是同源期（NTS注射后5至7天）。研究了在NTS之前（即预防性）或之后（即治疗性）给药的药物效果。2 从NTS注射前一天开始，每天口服剂量为150和250mg/kg的阿司匹林，可抑制异源期和同源期蛋白尿的发展，并使血清胆固醇水平降至正常水平。阿司匹林（每天250mg/kg，口服）对同源期已形成的蛋白尿无显著作用。3 从NTS注射前一天开始，每天口服剂量为3和5mg/kg的泼尼松龙，在异源期会使蛋白尿增加，同时抑制同源期蛋白尿的发展。泼尼松龙（每天5mg/kg，口服）对同源期已形成的蛋白尿无效。5 吲哚美辛（每天3mg/kg，口服）在异源期或同源期对蛋白尿均无显著影响。
