胸苷磷酸化酶。对5-取代2'-脱氧尿苷的底物特异性。
Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines.
作者信息
Nakayama C, Wataya Y, Meyer R B, Santi D V, Saneyoshi M, Ueda T
出版信息
J Med Chem. 1980 Aug;23(8):962-4. doi: 10.1021/jm00182a029.
PMID:7401121
Abstract
A continuous spectrophotometric assay for thymidine phosphorylase has been developed and used to analyze the substrate properties of a number of 5-substituted 2'-deoxyuridines. A QSAR was found which relates the catalytic efficiency for various substrates to a single variable, the inductive field constant F.
摘要
已开发出一种用于胸苷磷酸化酶的连续分光光度测定法，并用于分析多种5-取代2'-脱氧尿苷的底物特性。发现了一种定量构效关系，该关系将各种底物的催化效率与一个单一变量——诱导场常数F联系起来。
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