Jordan D K, Taysi K, Blackwell N L
J Med Genet. 1980 Jun;17(3):222-5. doi: 10.1136/jmg.17.3.222.
Several members in two families were found to have a pericentric inversion of chromosome 19. A review of four previous cases, together with those reported here, suggests that inversion of chromosome 19 is not related to the phenotypic features of the probands. Furthermore, there has been no report of an affected subject resulting from a duplication deficiency product of inverted chromosome 19 among the offspring of inversion heterozygotes. The suggested association of aneuploidy in the inversion carriers is also discussed.
在两个家族中发现有几名成员存在19号染色体的臂间倒位。对之前4例病例以及本文所报告病例的回顾表明，19号染色体倒位与先证者的表型特征无关。此外，在倒位杂合子的后代中，尚无因19号倒位染色体的重复缺失产物导致受累个体的报告。文中还讨论了倒位携带者中出现非整倍体的可能关联。
