脱髓鞘过程中胆固醇酯形成的一种可能机制：大鼠脑中卵磷脂：胆固醇酰基转移酶（LCAT）的活性
A possible mechanism for cholesteryl ester formation during demyelination: lecithin:cholesterol acyltransferase (LCAT) activity in rat brain.
作者信息
Amaducci L, Antuono P, Bartolini L, De Medio G E, Inzitari D, Porcellati G
出版信息
Neurochem Res. 1978 Dec;3(6):725-31. doi: 10.1007/BF00965995.
Lecithin:cholesterol acyltransferase (LCAT) activity has been examined in the rat by using a brain homogenate preparation as the phospholipid substrate and blood plasma as the enzyme source. LCAT activity was detected on using 60 mul of serum onwards. Successive experiments have also shown that LCAT activity is present in the edematous rat brain tissue homogenate when incubated with inactivated rat plasma as substrate. The results are discussed in relation to cholesteryl ester accumulation in brain during demyelinating diseases.
通过使用脑匀浆制剂作为磷脂底物并以血浆作为酶源，对大鼠体内的卵磷脂：胆固醇酰基转移酶（LCAT）活性进行了检测。使用60微升血清及以上时可检测到LCAT活性。后续实验还表明，当以灭活的大鼠血浆为底物进行孵育时，水肿大鼠脑组织匀浆中存在LCAT活性。结合脱髓鞘疾病期间脑中胆固醇酯的积累对这些结果进行了讨论。
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