L-抗坏血酸对豚鼠离体回肠标本的致痉挛作用。

Spasmogenic effects of L-ascorbic acid on the guinea pig isolated ileum preparation.

作者信息

Terada M, Hayashi S, Hayashi E

出版信息

Jpn J Pharmacol. 1980 Feb;30(1):21-7. doi: 10.1254/jjp.30.21.

DOI:10.1254/jjp.30.21

Abstract

The mechanism of actions of L-ascorbic acid (AA) on the guinea pig isolated ileum wasstudied. AA (neutralized, 10(-3) M) produced a stimulated motility (A effect) and a potentiation in acetylcholine (ACh)-induced contraction (B effect). The A effect showed a tachyphylaxis, and was inhibited by tetrodotoxin, atropine, adenosine, morphine, strychnine, Mg2+, papaverine and glucose- and Ca2+-free medium, but was stimulated by eserine. Thus, AA appears to have not only a direct myogenic effect but also a neurogenic effect by stimulating ACh release from intramural cholinergic nerves.

摘要

研究了L-抗坏血酸（AA）对豚鼠离体回肠的作用机制。AA（中和后的，10⁻³ M）可产生刺激运动性（A效应）以及增强乙酰胆碱（ACh）诱导的收缩（B效应）。A效应表现出快速耐受性，并且受到河豚毒素、阿托品、腺苷、吗啡、士的宁、Mg²⁺、罂粟碱以及无葡萄糖和Ca²⁺培养基的抑制，但受到毒扁豆碱的刺激。因此，AA似乎不仅具有直接的肌源性效应，还具有通过刺激壁内胆碱能神经释放ACh而产生的神经源性效应。