Vikhert A M, Bogdanovich N K, Kiseleva Z M
Kardiologiia. 1980 Jul;20(7):75-80.
The hypothalamus was examined in cases of sudden heart death in 50 persons of both sexes whose ages ranged from 25 to 55. The microscopic and biochemical findings were compared with those in cases of heart death which had not occurred suddenly in patients with myocardial infarction of different duration (50 cases). It is shown that in sudden heart death diffuse edema of the white matter and dystonic changes in the microcirculation vessels develop in the hypothalamus. Biochemical examination discloses in the tissue of the hypothalamus in such cases a sharp decrease in the content of noradrenalin and the precursor of catecholamine synthesis DOPA and a marked increase in the level of adrenalin. It is assumed that there is a causative connection between vascular dystonia and the decrease in the noradrenalin level. An increase in the adrenalin content may be conducive to the intensification of cerebral hydrophilism.
对年龄在25岁至55岁之间的50例男女突然心脏死亡病例的下丘脑进行了检查。将微观和生化检查结果与不同病程心肌梗死患者非突然心脏死亡病例（50例）的结果进行了比较。结果表明，在突然心脏死亡病例中，下丘脑出现白质弥漫性水肿和微循环血管张力障碍性改变。生化检查显示，此类病例下丘脑组织中去甲肾上腺素和儿茶酚胺合成前体多巴的含量急剧下降，肾上腺素水平显著升高。据推测，血管张力障碍与去甲肾上腺素水平降低之间存在因果关系。肾上腺素含量的增加可能有助于增强脑亲水性。
