Frolov V A, Demurov E A, Efimova L V, Kazanskaia T A, Pukhlianko V P
Kardiologiia. 1980 Jul;20(7):92-5.
The effect of large doses (700 U/kg daily for 6 days) of heparin on the heart contractile function, myocardial morphology, content of free fatty acids in the blood, and the activity of tri- and monoglycerin lipase in blood plasma and heart tissue of intact rabbits was studied 24, 72 hours and 6 days after the beginning of heparin administration. It was established that the activity of lipolytic enzymes intensified, the concentration of free fatty acids in blood plasma grows, and the myocardial contractility increases after heparin administration. The phase structure of the cardiac cycle is simultaneously disturbed slightly. It is concluded that the intensification of lipolysis plays a role in increasing the myocardial contractility.
研究了大剂量（每天700 U/kg，共6天）肝素对完整家兔心脏收缩功能、心肌形态、血液中游离脂肪酸含量以及血浆和心脏组织中甘油三酯脂肪酶和甘油单酯脂肪酶活性的影响，观察时间为肝素给药开始后的24小时、72小时和6天。结果表明，肝素给药后脂解酶活性增强，血浆中游离脂肪酸浓度升高，心肌收缩力增加，同时心动周期的相位结构略有紊乱。得出结论：脂解作用增强在增加心肌收缩力方面发挥了作用。
