Frolov V A, Demurov E A, Kazanskaia T A, Puklianko V P, Tsypin E S
Kardiologiia. 1979 Jan;19(1):87-93.
It was established in rabbit experiments that in acute focal myocardial ischemia induced by ligation of the descending branch of the left coronary artery, diminution of the force of cardiac contractions and an increase in the content of free fatty acids in blood plasma are observed. Progressing intramyocardial lipolysis is noted for 6 days. Lipolysis blockade with large doses of nicotinic acid leads to an extremely sharp drop in the contractile force of the heart in experimental animals with acute focal myocardial ischemia and to drastic damage of the myocardial ultrastructures as well as to disorders of the metabolism of intracellular lipids.
通过兔实验证实，在结扎左冠状动脉降支诱发急性局灶性心肌缺血时，可观察到心脏收缩力减弱及血浆中游离脂肪酸含量增加。持续6天可观察到心肌内脂解作用不断进展。大剂量烟酸阻断脂解作用会导致急性局灶性心肌缺血实验动物的心脏收缩力急剧下降，心肌超微结构严重受损，以及细胞内脂质代谢紊乱。
