Check I J, Hunter R L, Lounsbury B, Rosenberg K, Matz G
Laryngoscope. 1980 Aug;90(8 Pt 1):1281-90.
A battery of immunologic tests were performed on 42 patients with recurrent cancer of the head and neck whose median survival time was 6.8 months. Two tests correlated with survival: total white blood cell (WBC) count and the percentage of lymphoid cells (%LG) in the Ficoll-Hypaque gradient separated leukocyte fraction of blood. Patients with abnormally low values of %LB had a poor prognosis, as did patients who had greater than 8000 WBC count. Of the variation in %LG, 43% was due to the differences in differential WBC counts among the patients, with the remaining variation attributed to changes in the buoyant densities of the leukocytes. These data suggest that further study of the factors effecting buoyant density of cells may be clinically useful.
对42例复发性头颈癌患者进行了一系列免疫学检测，这些患者的中位生存时间为6.8个月。有两项检测结果与生存情况相关：全白细胞（WBC）计数以及在Ficoll-泛影葡胺梯度分离的血液白细胞组分中淋巴细胞的百分比（%LG）。%LB值异常低的患者预后较差，白细胞计数高于8000的患者也是如此。在%LG的变化中，43%是由于患者之间白细胞分类计数的差异，其余的变化归因于白细胞浮力密度的改变。这些数据表明，进一步研究影响细胞浮力密度的因素可能具有临床意义。
