Gray T, Wise R A
Pharmacol Biochem Behav. 1980 Jun;12(6):931-5. doi: 10.1016/0091-3057(80)90455-4.
Lever pressing for food on a variable interval (2.5 min) schedule was challenged by pretreatment with a 1.0 mg/kg dose of the dopamine receptor blocker pimozide. Large decreases in response rate were recorded even during the first few minutes of the test session before the rats had received any reinforcement. Pimozide also caused extinction-like effects, but it was clear, from comparisons between pimozide-treated rats that were rewarded and pimozide-treated rats that were not rewarded, that the rewarding effects of food were not totally blocked. It is suggested that an important aspect of the pimozide-produced response decrement is its effect on the incentive motivational properties of food-associated apparatus cues known to be important in sustaining responding under extinction and partial reinforcement conditions.
在可变间隔（2.5分钟）的食物按压杠杆实验中，用1.0毫克/千克剂量的多巴胺受体阻滞剂匹莫齐特进行预处理对实验造成了挑战。即使在测试阶段的最初几分钟，即大鼠尚未获得任何强化之前，反应率就出现了大幅下降。匹莫齐特还产生了类似消退的效应，但从对接受奖励的匹莫齐特处理大鼠和未接受奖励的匹莫齐特处理大鼠的比较中可以清楚地看出，食物的奖励效应并未被完全阻断。有人认为，匹莫齐特产生的反应减少的一个重要方面是它对与食物相关的装置线索的激励动机特性的影响，已知这些线索在消退和部分强化条件下维持反应中很重要。
