Tombaugh T N, Anisman H, Tombaugh J
Psychopharmacology (Berl). 1980;70(1):19-28. doi: 10.1007/BF00432365.
Response decrements in an operant task produced by either extinction or by the dopamine receptor blocker pimozide were examined in three experiments which employed intermittent reinforcement schedules. In contrast to the congruency between these treatments previously observed following continuous reinforcement training, treatment with pimozide was markedly more effective than extinction in decreasing performance after training with variable interval, fixed interval, and fixed ratio reinforcement. The two treatments also produced substantially different patterns of responding. A shift from extinction to pimozide did not alter the progressive decline in response rate over days, but a shift from pimozide to extinction caused a pronounced increase of performance. These results indicate that the pimozide and extinction treatment did not produce functionally equivalent effects, and that the role of dopamine on reward processes should not be inferred from comparisons between pimozide and extinction.
在三个采用间歇性强化程序的实验中，研究了消退或多巴胺受体阻滞剂匹莫齐特所导致的操作性任务中的反应减少情况。与之前在连续强化训练后观察到的这些处理之间的一致性不同，在用可变间隔、固定间隔和固定比率强化进行训练后，匹莫齐特处理在降低表现方面比消退明显更有效。这两种处理还产生了截然不同的反应模式。从消退转变为匹莫齐特处理并没有改变反应率随天数的逐渐下降，但从匹莫齐特转变为消退则导致表现显著增加。这些结果表明，匹莫齐特和消退处理并没有产生功能上等效的效果，并且不应从匹莫齐特和消退之间的比较中推断多巴胺在奖励过程中的作用。
