• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

趋化因子诱导的人中性粒细胞中环磷酸腺苷水平的变化。

Chemotaxin-induced changes in cyclic adenosine monophosphate levels in human neutrophils.

作者信息

Marx R S, McCall C E, Bass D A

出版信息

Infect Immun. 1980 Jul;29(1):284-6. doi: 10.1128/iai.29.1.284-286.1980.

DOI:10.1128/iai.29.1.284-286.1980
PMID:6249759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC551110/
Abstract

Incubation of the chemotactic agent N-formyl-methionyl-leucyl-phenylalanine with human neutrophils produced a rapid elevation of the intracellular level of cyclic adenosine monophosphate (cAMP). This cAMP spike occurred within 30 s after exposure and returned to normal by 5 min.

摘要

趋化剂N-甲酰甲硫氨酰亮氨酰苯丙氨酸与人中性粒细胞一起温育，可使细胞内环磷酸腺苷（cAMP）水平迅速升高。这种cAMP峰值在暴露后30秒内出现，并在5分钟时恢复正常。

相似文献

1
Chemotaxin-induced changes in cyclic adenosine monophosphate levels in human neutrophils.趋化因子诱导的人中性粒细胞中环磷酸腺苷水平的变化。
Infect Immun. 1980 Jul;29(1):284-6. doi: 10.1128/iai.29.1.284-286.1980.
2
Response of adenosine cyclic 3',5'-monophosphate level in rabbit neutrophils to the chemotactic peptide formyl-methionyl-leucyl-phenylalanine.兔中性粒细胞中3',5'-环磷酸腺苷水平对趋化肽甲酰甲硫氨酰亮氨酰苯丙氨酸的反应
Mol Pharmacol. 1979 Sep;16(2):473-81.
3
Antagonists of the formylated peptide chemoattractants: structure-activity comparisons with formyl-methionyl-leucyl-phenylalanine-OH.甲酰化肽趋化因子拮抗剂：与甲酰-甲硫氨酰-亮氨酰-苯丙氨酸-OH的构效关系比较
Kroc Found Ser. 1981;14:161-8.
4
Similarities in the mechanisms by which formyl-methionyl-leucyl-phenylalanine, arachidonic acid and leukotriene B4 increase calcium and sodium influxes in rabbit neutrophils.甲酰甲硫氨酰亮氨酰苯丙氨酸、花生四烯酸和白三烯B4增加兔中性粒细胞钙内流和钠内流的机制的相似性。
Biochem Biophys Res Commun. 1981 Nov 16;103(1):227-32. doi: 10.1016/0006-291x(81)91683-1.
5
Stimulation of granulocyte adhesiveness by the chemotactic peptide N-formyl-L-methionyl-L-phenylalanine.趋化肽N-甲酰-L-蛋氨酰-L-苯丙氨酸对粒细胞黏附性的刺激作用。
Res Exp Med (Berl). 1980;177(1):19-22. doi: 10.1007/BF01851628.
6
Endogenous phospholipid metabolism in stimulated neutrophils differential activation by FMLP and PMA.受刺激的中性粒细胞中内源性磷脂代谢：FMLP和PMA的差异激活
Biochem Biophys Res Commun. 1982 Aug;107(3):951-8. doi: 10.1016/0006-291x(82)90615-5.
7
Deactivation of the effects of F-Met-Leu-Phe and leukotriene B4 on calcium mobilization in rabbit neutrophils.F-甲硫-亮-苯丙氨酸和白三烯B4对兔中性粒细胞钙动员作用的失活
Biochem Biophys Res Commun. 1981 Nov 30;103(2):766-73. doi: 10.1016/0006-291x(81)90515-5.
8
Stimulus-specific deactivation of chemotactic factor-induced cyclic AMP response and superoxide generation by human neutrophils.趋化因子诱导的人中性粒细胞环磷酸腺苷反应及超氧化物生成的刺激特异性失活
J Clin Invest. 1980 Oct;66(4):736-47. doi: 10.1172/JCI109911.
9
The synthetic chemotactic peptide formyl-methionyl-leucyl-phenylalanine causes an increase in actin associated with the cytoskeleton in rabbit neutrophils.合成趋化肽甲酰甲硫氨酰亮氨酰苯丙氨酸会使兔中性粒细胞中与细胞骨架相关的肌动蛋白增加。
Biochem Biophys Res Commun. 1982 Oct 15;108(3):1144-9. doi: 10.1016/0006-291x(82)92120-9.
10
Chemotactic deactivation of human neutrophils: relationship to loss of cytotaxin receptor function and temporal nature of the phenomenon.人中性粒细胞的趋化失活：与细胞趋化素受体功能丧失及该现象的时间特性的关系。
J Reticuloendothel Soc. 1980 Sep;28(3):285-94.

引用本文的文献

1
Cyclic nucleotide changes induced in human leukocytes by a product of axenically grown Entamoeba histolytica that inhibits human monocyte locomotion.由无菌培养的溶组织内阿米巴的一种产物诱导人白细胞中发生的环核苷酸变化，该产物可抑制人单核细胞运动。
Parasitol Res. 1995;81(2):158-62. doi: 10.1007/BF00931623.
2
Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes.鸟嘌呤核苷酸调节人多形核白细胞上寡肽趋化因子受体的结合亲和力。
J Clin Invest. 1983 Sep;72(3):748-53. doi: 10.1172/JCI111045.
3
Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line.百日咳毒素对人-鼠杂交细胞系趋化作用及膜蛋白ADP-核糖基化的抑制作用
Proc Natl Acad Sci U S A. 1985 May;82(9):2637-41. doi: 10.1073/pnas.82.9.2637.
4
Cholera toxin inhibits chemotaxis by a cAMP-independent mechanism.霍乱毒素通过一种不依赖环磷酸腺苷（cAMP）的机制抑制趋化作用。
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7475-9. doi: 10.1073/pnas.82.22.7475.

本文引用的文献

1
The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils.合成肽作为中性粒细胞趋化因子和溶酶体分泌诱导剂的构效关系。
J Exp Med. 1976 May 1;143(5):1154-69. doi: 10.1084/jem.143.5.1154.
2
N-formylmethionyl peptides as chemoattractants for leucocytes.N-甲酰甲硫氨酰肽作为白细胞的趋化因子。
Proc Natl Acad Sci U S A. 1975 Mar;72(3):1059-62. doi: 10.1073/pnas.72.3.1059.
3
Neutrophil aggregation and swelling induced by chemotactic agents.趋化因子诱导的中性粒细胞聚集和肿胀。
J Immunol. 1977 Jul;119(1):232-9.
4
Chemotactic factor-induced release of membrane calcium in rabbit neutrophils.趋化因子诱导兔中性粒细胞释放膜钙
Science. 1979 Feb 2;203(4379):461-3. doi: 10.1126/science.760200.
5
A simplified procedure for cyclic nucleotide radioimmunoassay and its application to human blood leukocytes.一种简化的环核苷酸放射免疫测定方法及其在人血白细胞中的应用。
J Immunol Methods. 1978;19(4):301-8. doi: 10.1016/0022-1759(78)90014-5.
6
A possible role of arachidonic acid in human neutrophil aggregation and degranulation.花生四烯酸在人类中性粒细胞聚集和脱颗粒中的可能作用。
Am J Pathol. 1979 Sep;96(3):799-810.
7
Substances which aggregate neutrophils. Mechanism of action.使中性粒细胞聚集的物质。作用机制。
Am J Pathol. 1978 Jul;92(1):155-66.
8
Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes.完整人多形核白细胞上特异性C5a受体的证实。
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3943-7. doi: 10.1073/pnas.75.8.3943.
9
Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes.人多形核白细胞上趋化肽的特异性受体位点。
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1204-8. doi: 10.1073/pnas.74.3.1204.
10
Enhancement of neutrophil chemotaxis and alteration of levels of cellular cyclic nucleotides by levamisole.左旋咪唑对中性粒细胞趋化性的增强作用及细胞环核苷酸水平的改变
J Infect Dis. 1978 Oct;138(4):437-44. doi: 10.1093/infdis/138.4.437.