用减毒活流感病毒进行鼻腔接种后的分泌性免疫反应。
Secretory immune response after nasal vaccination with live attenuated influenza viruses.
作者信息
Crifö S, Vella S, Filiaci F, Resta S, Rocchi G
出版信息
Rhinology. 1980 Jun;18(2):87-92.
Immunoglobulins and virus-specific antibody in nasal secretions were measured in 18 volunteers before and after intra-nasal vaccination with two live-attenuated type A influenza virus strains. Specific serum antibody rises occurred in 14 out of 18 vaccinees; of those, 11 and 10, respectively, showed significant increase of IgA concentration and of virus-specific antibody in nasal secretions collected 2-4 weeks after vaccination. In one case, a volunteer showed appreciable increase of virus neutralizing antibody in nasal secretions without increase of local IgA concentration and of serum HI antibody. This data indicate that administration of live virus vaccines by upper respiratory route confers effective immunity associated with local antibody synthesis.
在18名志愿者鼻内接种两种减毒活甲型流感病毒株前后，检测了他们鼻分泌物中的免疫球蛋白和病毒特异性抗体。18名接种者中有14人血清特异性抗体升高；其中，分别有11人和10人在接种后2 - 4周采集的鼻分泌物中，IgA浓度和病毒特异性抗体显著增加。有1例志愿者鼻分泌物中的病毒中和抗体明显增加，但局部IgA浓度和血清血凝抑制（HI）抗体未增加。这些数据表明，通过上呼吸道途径接种活病毒疫苗可产生与局部抗体合成相关的有效免疫。
Zotero 插件