Dynamics and specificity of influenza virus antibodies as well as IgE values in serum and nasal fluid after repeated local application of live bivalent influenza vaccine.

A long term study with bivalent live influenza vaccine was carried out in 18 subjects with no previous history of egg protein hypersensitivity. Experimental conditions included a nine-fold vaccination schedule with collection of serum and nasal fluid. The parameters studied were determination of serum and local antibody formation as well as the demonstration of specific IgE antibodies in serum and nasal fluid. HI antibody response was observed in 100% of the vaccinees against vaccine related strains but not to antigenically remote isolates. NI antibodies could be demonstrated in serums and to some extent in nasal fluids. Special attention was given to induction of specific IgE antibodies to egg protein, however no indication for a vaccine induced sensitization could be detected when total and specific IgE concentrations of serum and nasal fluid were determined.