Callow K A, Parry H F, Sergeant M, Tyrrell D A
MRC Common Cold Unit, Harvard Hospital, Salisbury, Wiltshire, UK.
Epidemiol Infect. 1990 Oct;105(2):435-46. doi: 10.1017/s0950268800048019.
After preliminary trials, the detailed changes in the concentration of specific circulating and local antibodies were followed in 15 volunteers inoculated with coronavirus 229E. Ten of them, who had significantly lower concentrations of pre-existing antibody than the rest, became infected and eight of these developed colds. A limited investigation of circulating lymphocyte populations showed some lymphocytopenia in infected volunteers. In this group, antibody concentrations started to increase 1 week after inoculation and reached a maximum about 1 week later. Thereafter antibody titres slowly declined. Although concentrations were still slightly raised 1 year later, this did not always prevent reinfection when volunteers were then challenged with the homologous virus. However, the period of virus shedding was shorter than before and none developed a cold. All of the uninfected group were infected on re-challenge although they also appeared to show some resistance to disease and in the extent of infection. These results are discussed with reference to natural infections with coronavirus and with other infections, such as rhinovirus infections.
经过初步试验，对15名接种了229E冠状病毒的志愿者体内特定循环抗体和局部抗体浓度的详细变化进行了跟踪。其中10名志愿者，其预先存在的抗体浓度明显低于其余志愿者，他们被感染，其中8人患上了感冒。对循环淋巴细胞群体的有限研究显示，受感染的志愿者出现了一些淋巴细胞减少。在这组志愿者中，抗体浓度在接种后1周开始上升，并在大约1周后达到峰值。此后抗体滴度缓慢下降。尽管1年后浓度仍略有升高，但当志愿者随后受到同源病毒攻击时，这并不总能防止再次感染。然而，病毒排出期比以前短，且没有人患上感冒。所有未感染组的志愿者在再次受到攻击时都被感染了，尽管他们似乎也表现出对疾病和感染程度的一些抵抗力。将结合冠状病毒的自然感染以及其他感染（如鼻病毒感染）对这些结果进行讨论。
