Yamamoto K, Tajima K, Mizutani T
Toxicol Lett. 1980 Aug;6(3):173-5. doi: 10.1016/0378-4274(80)90187-3.
the acute toxicity of butylated hydroxytoluene (BHT) and four of its metabolites, 2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadien-1-one (BHT-OOH), 2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one (BHT-OH), 2,6-di-tert-butyl-p-benzoquinone (DBQ), and 2,6-di-tert-butyl-4-[(methylthio)methyl]phenol (BHT-SCH3) was studied in young male mice following intraperitonel administration. The i.p. LD50 values of BHT, BHT-OOH, BHT-OH, DBQ, and BHT-SCH3 wee 3550, 190, above 1600, 2270, and 1840 mg/kg, respectively. These results suggest that BHT-OOH probably is the most toxic metabolite of BHt.
研究了丁基羟基甲苯（BHT）及其四种代谢产物2,6-二叔丁基-4-氢过氧-4-甲基-2,5-环己二烯-1-酮（BHT-OOH）、2,6-二叔丁基-4-羟基-4-甲基-2,5-环己二烯-1-酮（BHT-OH）、2,6-二叔丁基对苯醌（DBQ）和2,6-二叔丁基-4-[(甲硫基)甲基]苯酚（BHT-SCH3）对雄性幼鼠腹腔注射后的急性毒性。BHT、BHT-OOH、BHT-OH、DBQ和BHT-SCH3的腹腔注射半数致死量（LD50）值分别为3550、190、高于1600、2270和1840mg/kg。这些结果表明，BHT-OOH可能是BHT毒性最强的代谢产物。
