Lewis A J
Agents Actions. 1980 Jun;10(3):258-65. doi: 10.1007/BF02025945.
The effects of a number of steroids administered intra-articularly in a chronic model of fibrin-induced monoarticular arthritis in the rabbit have been investigated. Org 6216 hydrocortisone acetate, prednisolone tertiary butyl acetate and triamcinolone hexacetonide each suppressed the joint swelling produced 14 days after antigen challenge. These anti-inflammatory effects lasted for at least 7 days. Hydrocortisone semisuccinate was inactive in this model. In addition, the effects of the same compounds and several other anti-inflammatory steroids and indomethacin administered locally with adjuvant was assessed on the resultant paw oedema produced in the rat. The local anti-inflammatory activity, the duration of action and the systemic effects of these drugs varied considerably and only Org 6216, hydrocortisone acetate, prednisolone tertiary butyl acetate and indomethacin produced anti-inflammatory effects throughout the 4 days of the experiments and were devoid of significant adrenolytic and thymolytic activity.
研究了在兔纤维蛋白诱导的单关节炎慢性模型中关节内注射多种类固醇的效果。Org 6216、醋酸氢化可的松、叔丁醋酸泼尼松龙和己曲安奈德均能抑制抗原攻击14天后产生的关节肿胀。这些抗炎作用至少持续7天。半琥珀酸氢化可的松在该模型中无活性。此外，还评估了相同化合物以及其他几种抗炎类固醇和吲哚美辛与佐剂局部给药对大鼠产生的爪部水肿的影响。这些药物的局部抗炎活性、作用持续时间和全身作用差异很大，只有Org 6216、醋酸氢化可的松、叔丁醋酸泼尼松龙和吲哚美辛在整个4天的实验中产生了抗炎作用，且没有明显的肾上腺溶解和胸腺溶解活性。
