类风湿性滑膜炎中三种关节内注射泼尼松龙类似物的热成像评估。
A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.
作者信息
Esselinckx W, Bacon P A, Ring E F, Crooke D, Collins A J, Demottaz D
出版信息
Br J Clin Pharmacol. 1978 May;5(5):447-51. doi: 10.1111/j.1365-2125.1978.tb01653.x.
Abstract
1 Three intra-articular prednisolone analogues have been studied in a group of forty-six rheumatoid arthritic subjects. Each compound was tested at 50 mg and 100 mg dose over 3 weeks. 2 The anti-inflammatory effect was assessed by quantitative thermography. Systemic escape of the drug was monitored by plasma prednisolone and cortisol levels. 3 Both the systemic escape from the joint and the duration of effect on injected and uninjected knees were related to drug solubility. 4 Depression of plasma cortisol occurred with all three preparations and was most prolonged with the long-acting preparation. 5 Increasing the dose from 50 mg to 100 mg increased the antiflammatory effect only with the soluble acetate preparation.
摘要
1 在一组46名类风湿性关节炎患者中对三种关节内注射用泼尼松龙类似物进行了研究。每种化合物均以50毫克和100毫克的剂量进行了为期3周的测试。2 通过定量热成像评估抗炎效果。通过血浆泼尼松龙和皮质醇水平监测药物的全身逃逸情况。3 药物从关节的全身逃逸以及对注射和未注射膝关节的作用持续时间均与药物溶解度有关。4 所有三种制剂均导致血浆皮质醇降低，长效制剂导致的降低最为持久。5 仅可溶性醋酸盐制剂将剂量从50毫克增加到100毫克时抗炎效果增强。
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本文引用的文献
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Hydrocortisone and cortisone injected into arthritic joints; comparative effects of and use of hydrocortisone as a local antiarthritic agent.将氢化可的松和可的松注射入关节炎关节；氢化可的松作为局部抗关节炎药物的比较效果及应用
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Methylprednisolone acetate in intra-articular therapy. Clinical, biochemical, and chromatographic studies.醋酸甲泼尼龙在关节内治疗中的应用。临床、生化及色谱研究。
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Local injection of prednisolone TBA in the treatment of rheumatic diseases.
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Temperature and biochemical studies of joint inflammation. A preliminary investigation.关节炎症的温度及生化研究。一项初步调查。
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