Marcus R, Hunt C, Windhorst R, Jose J, Mandell R B
Am J Optom Physiol Opt. 1980 Jun;57(6):360-2. doi: 10.1097/00006324-198006000-00007.
The toxic potential of three major components of soft contact lenses was assessed in white mice. Accepted procedures for toxicological studies were used to evaluate the effects of 2-hydroxyethyl methacrylate, ethylene glycol, and methacrylic acid. No observable signs of gross toxicity were detected in any of the mice injected with the original doses. Larger doses of methacrylic acid produced ataxia, irregular breathing, convulsions, and death. From the concentrations of these chemicals normally occurring in contact lenses, no systemic toxic effects would be expected.
在小白鼠身上评估了软性隐形眼镜三种主要成分的潜在毒性。采用了公认的毒理学研究程序来评估甲基丙烯酸2-羟乙酯、乙二醇和甲基丙烯酸的影响。注射原始剂量的任何小鼠均未检测到明显的总体毒性迹象。较大剂量的甲基丙烯酸会导致共济失调、呼吸不规则、抽搐和死亡。根据隐形眼镜中这些化学物质的正常含量，预计不会产生全身毒性作用。
