异烟肼治疗后的迟发效应。
Late effects following isoniazid therapy.
作者信息
Boice J D, Fraumeni J F
出版信息
Am J Public Health. 1980 Sep;70(9):987-9. doi: 10.2105/ajph.70.9.987.
Abstract
Amont 338 women treated in Massachusetts with isoniazid (isonicotinic acid hydrazide = INH) for pulmonary tuberculosis, no excess cancer deaths occurred (8 observed vs 8.3 expected) after 23 years (12.9 mean) of follow-up. There was an excess of cancer deaths (54 vs 35.7) among 1,090 patients who did not receive INH, partly due to radiogenic breast cancer resulting from multiple chest fluoroscopies to monitor pneumothorax. Increased deaths from liver cirrhosis (5 vs 0.8) were observed following INH use, suggesting that chronic as well as acute liver disease complicate this treatment.
摘要
在马萨诸塞州接受异烟肼（异烟酸肼 = INH）治疗肺结核的338名女性中，经过23年（平均12.9年）的随访，未出现癌症死亡过量情况（观察到8例，预期8.3例）。在1090名未接受异烟肼治疗的患者中出现了癌症死亡过量情况（54例 vs 35.7例），部分原因是为监测气胸进行多次胸部荧光透视导致的放射性乳腺癌。使用异烟肼后观察到肝硬化导致的死亡增加（5例 vs 0.8例），这表明慢性以及急性肝病使这种治疗变得复杂。
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本文引用的文献
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