Zheng W, Blot W J, Liao M L, Wang Z X, Levin L I, Zhao J J, Fraumeni J F, Gao Y T
Shanghai Cancer Institute, People's Republic of China.
Br J Cancer. 1987 Oct;56(4):501-4. doi: 10.1038/bjc.1987.233.
In a population-based case-control study of lung cancer in Shanghai involving interviews during 1984-86 with 1,405 cancer patients and 1,495 controls, a significant 50% elevation in the risk of lung cancer, adjusted for cigarette smoking, was observed among persons who had a history of tuberculosis. Among those diagnosed with tuberculosis within the past 20 years, the risk exceeded 2.5-fold. In males the lung cancers tended to occur on the same side as the previous tuberculosis infection. For both sexes, the effect of recent tuberculosis was most apparent for adenocarcinoma and peripheral tumours. No relationship was found between lung cancer risk and the type of tuberculosis therapy, including use of isoniazid. The findings suggest that tuberculosis may predispose to lung cancer, with the association most apparent among recent survivors of the infection.
在一项基于人群的上海肺癌病例对照研究中，于1984年至1986年期间对1405名癌症患者和1495名对照进行了访谈。结果发现，有结核病史的人在调整吸烟因素后，患肺癌的风险显著升高了50%。在过去20年内被诊断为结核病的人群中，风险超过了2.5倍。在男性中，肺癌往往发生在先前结核感染的同一侧。对于两性而言，近期患结核病对腺癌和周围型肿瘤的影响最为明显。未发现肺癌风险与包括使用异烟肼在内的结核病治疗类型之间存在关联。这些发现表明，结核病可能易引发肺癌，这种关联在感染的近期幸存者中最为明显。
