Ekhart E, List W F
Prakt Anaesth. 1978 Dec;13(6):502-6.
The effect of etomidate on cerebro-spinal fluid pressure (CSFP) was investigated in 25 patients. Mean arterial blood pressure (MAP), heart rate (BPM) and blood gases were measured additionally. Cerebral perfusion pressure (CPP) was calculated from the difference MAP minus CSFP. Etomidate lowered CSFP (p less than 0,01 paired Student t-test). Ketamine-induced increase of CSFP (p less than 0,01) was normalized by etomidate. Premedication with etomidate delayed ketamine-induced increase of CSFP, which dropped to normal after a second dose of etomidate. The effect in reducing CSFP of etomidate was seen despite elevation of pCO2(p less than 0,01) in all patients breathing spontaneously.
在25例患者中研究了依托咪酯对脑脊液压力（CSFP）的影响。另外还测量了平均动脉血压（MAP）、心率（BPM）和血气。脑灌注压（CPP）通过MAP减去CSFP的差值计算得出。依托咪酯降低了CSFP（配对t检验，p<0.01）。氯胺酮引起的CSFP升高（p<0.01）被依托咪酯恢复正常。依托咪酯预处理延迟了氯胺酮引起的CSFP升高，在给予第二剂依托咪酯后CSFP降至正常。尽管所有自主呼吸患者的pCO2升高（p<0.01），但仍观察到依托咪酯降低CSFP的效果。
