Ekhart E, List W F, Vadon P, Oberbauer R
Wien Med Wochenschr. 1979 Sep 30;129(17):471-5.
The effect of alphaxalon + alphadolon-acetate on cerebrospinal fluid pressure (CSFP), mean arterial blood pressure (MPA), heart rate (BMP) and blood gases was investigated in 18 patients. Cerebral perfusion pressure (CPP) was calculated from the difference MAP minus CSFP. Alphaxalon + alphadolon-acetate lowered the normal CSFP and normalized ketamin induced increase of CSFP. Premedication with alphaxalon + alphadolon-acetate delayed the ketamin induced increase of CSFP, which returned to norm after a second dose of alphaxalon + alphadolon-acetate. This effect was seen despite elevation of pCO2 in all patients breathing spontaneously.
在18例患者中研究了α-羟龙+醋酸α-羟孕酮对脑脊液压力（CSFP）、平均动脉血压（MPA）、心率（BMP）和血气的影响。脑灌注压（CPP）通过平均动脉压（MAP）减去脑脊液压力（CSFP）的差值计算得出。α-羟龙+醋酸α-羟孕酮降低了正常脑脊液压力，并使氯胺酮引起的脑脊液压力升高恢复正常。术前使用α-羟龙+醋酸α-羟孕酮可延迟氯胺酮引起的脑脊液压力升高，在第二次给予α-羟龙+醋酸α-羟孕酮后恢复正常。尽管所有自主呼吸的患者二氧化碳分压（pCO2）升高，但仍观察到这种效果。
