Quelhorst E, Schuenemann B, Mietzsch G, Jacob I
Proc Eur Dial Transplant Assoc. 1978;15:205-12.
Thirty-two patients with advanced chronic renal insufficiency due to juvenile onset diabetes mellitus were submitted to dialytic treatment, 16 with intermittent haemodialysis and 16 with peritoneal dialysis. Both groups were similar with respect to onset of diabetes, course of renal insufficiency, as well as start and duration of dialysis treatment (382 and 389 patient months respectively). Patients on haemodialysis showed a more rapid progress of retinopathy and neuropathy, whereas the control of hypertension proved to be more difficult with peritoneal dialysis. A reduced peritoneal dialysance of urea, demonstrated in patients with diabetic nephropathy, could be improved by dipyridamole administration, whereas this drug showed no effect on the dialysances of urea and inulin in patients with chronic renal insufficiency of non-diabetic origin. There were no differences between the survival rates of the two groups which were substantially lower than in non-diabetic dialysis patients.
32例因青少年期发病的糖尿病而导致晚期慢性肾功能不全的患者接受了透析治疗，其中16例进行间歇性血液透析，16例进行腹膜透析。两组在糖尿病发病情况、肾功能不全病程以及透析治疗的开始时间和持续时间（分别为382和389患者月）方面相似。接受血液透析的患者视网膜病变和神经病变进展更快，而腹膜透析时高血压的控制更为困难。糖尿病肾病患者中尿素腹膜清除率降低，给予双嘧达莫后可得到改善，而该药物对非糖尿病性慢性肾功能不全患者的尿素和菊粉清除率无影响。两组的生存率无差异，均显著低于非糖尿病透析患者。
