Garcia M L, Benavides J, Valdivieso F
Biochim Biophys Acta. 1980 Aug 14;600(3):922-30. doi: 10.1016/0005-2736(80)90494-0.
Ketone body uptake by renal brush border vesicles has been investigated. Ketone bodies enter into the brush border vesicles by a carrier-mediated process. The uptake is dependent on an Na+ gradient ([Na+]outside>[Na+]inside) and is electroneutral. The uptake is transport into an osmotically active space and not a binding artifact as indicated by the effect of increasing the medium osmolarity. A pH gradient (alkaline inside) also stimulates the ketone body uptake. Acetoacetate and 3-hydroxybutyrate share the same carrier as demonstrated by the accelerated exchange diffusion and mutual inhibitory effects.
已经对肾刷状缘小泡摄取酮体的情况进行了研究。酮体通过载体介导的过程进入刷状缘小泡。摄取依赖于Na⁺梯度（细胞外[Na⁺]>细胞内[Na⁺]），且呈电中性。摄取是转运到一个具有渗透活性的空间，而不是如增加培养基渗透压的作用所表明的那样是一种结合假象。pH梯度（内部呈碱性）也会刺激酮体摄取。通过加速交换扩散和相互抑制作用表明，乙酰乙酸和3-羟基丁酸共用同一载体。
