Kapetanović I M, Kupferberg H J
Biomed Mass Spectrom. 1980 Feb;7(2):47-52. doi: 10.1002/bms.1200070202.
A pharmacokinetic study of phenobarbital labeled with stable (nonradioactive) isotopes [1,3-15N, 2-13C] was conducted in patients undergoing chronic drug treatment for epilepsy. A pulse dose of stable isotope labeled phenobarbital was administered when plasma concentration of unlabeled phenobarbital was at a steady state. Plasma concentration-time profile of the labeled drug was obtained from serial blood samples using a gas chromatography mass spectrometry computer system. The data were used for pharmacokinetic analysis of the absorption, elimination and clearance of phenobarbital. Currently, this method is being used to study mechanisms of drug-drug interactions during antiepileptic therapy.
一项针对癫痫慢性药物治疗患者开展了用稳定（非放射性）同位素[1,3-15N, 2-13C]标记苯巴比妥的药代动力学研究。当未标记苯巴比妥的血浆浓度处于稳态时，给予一剂脉冲剂量的稳定同位素标记苯巴比妥。使用气相色谱质谱计算机系统从系列血样中获取标记药物的血浆浓度-时间曲线。这些数据用于苯巴比妥吸收、消除和清除的药代动力学分析。目前，该方法正用于研究抗癫痫治疗期间药物-药物相互作用的机制。
