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[枯否细胞阻断对急性中毒性肝炎发展的影响]

[Effect of Kupffer cell blockade on the development of acute toxic hepatitis].

作者信息

Kutina S N, Maianskiĭ D N

出版信息

Biull Eksp Biol Med. 1980 Aug;90(8):150-1.

PMID:7407385
Abstract

The blockade of Kupffer cells was induced in Wistar rats by intravenous injection of colloid iron, brand P-100 phi, in a 5% starch followed after two hours by subcutaneous administration of 0.2 ml of 40% CCl per 100 g body weight. During the blockade of course of CCl4-induced acute hepatitis was significantly modified that was shown by the tendency to scattering of hepatocyte injury and by delayed liver tissue recovery.

摘要

通过静脉注射胶体铁(品牌P - 100 phi)诱导Wistar大鼠库普弗细胞的阻断,胶体铁溶于5%的淀粉溶液中,两小时后,以每100克体重皮下注射0.2毫升40%的四氯化碳。在阻断过程中,四氯化碳诱导的急性肝炎病程明显改变,表现为肝细胞损伤呈散在性趋势以及肝组织恢复延迟。

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