[Liver regeneration characteristics in young rats in allyl alcohol lesion of the periportal areas].

The authors analyzed ultrastructural changes in hepatocytes of weanling rats, induced by allyl alcohol (0.03 ml/kg). The most severe lesions developed in mitochondria of the periportal field of liver lobules during the first 24 hours following alcohol administration. Early signs of the regeneration were also seen in the periportal field 24 hours after exposure. Three types of dark hepatocytes were distinguished: (1) polygonal cells with the dilated endoplasmic reticulum, increased size and number of mitochodria; (2) stellate cells with the remarkably increased rough endoplasmic reticulum showing free ribosomes and a lot of large mitochondria; (3) cells consisting of irregularly arranged rough endoplasmic reticulum and a great number of small mitochondria. Large hepatocytes containing an insignificant number of organellas were seen in the later stages of the regeneration. The data obtained warranted a suggestion that the cells described represent different phases of hepatocytic regeneration.