D-普萘洛尔和DL-普萘洛尔均可降低L-甲状腺素向L-三碘甲状腺原氨酸的转化。
D-propranolol and DL-propranolol both decrease conversion of L-thyroxine to L-triiodothyronine.
作者信息
Heyma P, Larkins R G, Higginbotham L, Ng K W
出版信息
Br Med J. 1980 Jul 5;281(6232):24-5. doi: 10.1136/bmj.281.6232.24.
Abstract
The effects of propranolol (DL-propranolol) and D-propranolol on thyroid hormone metabolism were studied in six euthyroid volunteers receiving L-thyroxine (T4) and six hypothyroid patients receiving T4 replacement. D-propranolol as well as propranolol decreased L-triiodothyronine (T3) concentrations and the ratio of T3 to T4 in the euthyroid subjects, and D-propranolol decreased these variables in the subjects with hypothyroidism (propranolol was not given to this group). It is concluded from this study and from parallel invitro investigations that the effect of propranolol on the conversion of T4 to T3 is unrelated to its beta-adrenergic blocking activity, and that at low therapeutic doses propranolol may exert appreciable "membrane-stabilising" effects in vivo.
摘要
在6名接受左旋甲状腺素（T4）的甲状腺功能正常志愿者和6名接受T4替代治疗的甲状腺功能减退患者中，研究了普萘洛尔（DL-普萘洛尔）和D-普萘洛尔对甲状腺激素代谢的影响。D-普萘洛尔以及普萘洛尔降低了甲状腺功能正常受试者的L-三碘甲状腺原氨酸（T3）浓度和T3与T4的比值，D-普萘洛尔降低了甲状腺功能减退受试者的这些变量（该组未给予普萘洛尔）。从这项研究以及平行的体外研究得出结论，普萘洛尔对T4向T3转化的作用与其β-肾上腺素能阻断活性无关，并且在低治疗剂量下，普萘洛尔可能在体内发挥明显的“膜稳定”作用。
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