猪的血浆次黄嘌呤浓度。缺氧时的一种预后辅助指标。

Plasma hypoxanthine concentrations in pigs. A prognostic aid in hypoxia.

作者信息

Saugstad O D, Aasen A O

出版信息

Eur Surg Res. 1980;12(2):123-9. doi: 10.1159/000128117.

Abstract

Hypoxemia was induced in pigs by artificial ventilation with 7% oxygen. Death occurred after 21--99 min (mean 48 min). The plasma hypoxanthine and base deficit concentrations increased linearly during hypoxemia and were significantly elevated after 5 min compared to initial values. The correlation between hypoxanthine and base deficit was good (p < 0.001, r = 0.68). The rate of increase of plasma hypoxanthine concentration was correlated with survival time and a significant correlation was found between the negative slope of hypoxanthine increased and survival. Death occurred in all animals when the hypoxanthine concentrations exceeded about 125 mumol/l. These findings indicate that the plasma concentration and the rate of increase of hypoxanthine specifically and sensitively reflect tissue hypoxia.

摘要

通过用7%的氧气进行人工通气在猪身上诱发低氧血症。死亡发生在21 - 99分钟后（平均48分钟）。在低氧血症期间，血浆次黄嘌呤和碱缺失浓度呈线性增加，并且在5分钟后与初始值相比显著升高。次黄嘌呤与碱缺失之间的相关性良好（p < 0.001，r = 0.68）。血浆次黄嘌呤浓度的增加速率与存活时间相关，并且在次黄嘌呤增加的负斜率与存活之间发现了显著相关性。当次黄嘌呤浓度超过约125μmol/l时，所有动物均死亡。这些发现表明，血浆次黄嘌呤浓度及其增加速率能特异性且灵敏地反映组织缺氧。