Saugstad O D, Bo G, Ostrem T, Aasen A O
Eur Surg Res. 1977;9(1):23-33. doi: 10.1159/000127922.
Tissue hypoxia was induced in one group of dogs by clamping of the endotracheal tube and in another group by artificial ventilation with a mixture of nitrogen and air. The hypoxanthine concentration of venous and arterial plasma increased significantly during severe hypoxemia. When the hypoxemia was relieved, an increased venous-arterial hypoxanthine difference appeared indicating that the lung metabolism of hypoxanthine was slowed down during alveolar hypoxia. It is concluded that the level of plasma hypoxanthine in dogs during hypoxemia is dependent on the degree of tissue hypoxia, peripheral vasoregulation, and lung metabolism.
一组犬通过夹闭气管插管诱导组织缺氧，另一组通过用氮气和空气的混合物进行人工通气诱导组织缺氧。在严重低氧血症期间，静脉和动脉血浆中的次黄嘌呤浓度显著增加。当低氧血症缓解时，静脉 - 动脉次黄嘌呤差值增加，表明在肺泡缺氧期间次黄嘌呤的肺代谢减慢。得出的结论是，犬在低氧血症期间血浆次黄嘌呤水平取决于组织缺氧程度、外周血管调节和肺代谢。
