Tuchschmid P E, Boutellier U, Koller E A, Duc G V
Pediatr Res. 1981 Jan;15(1):28-33. doi: 10.1203/00006450-198101000-00007.
High altitude-induced hypoxemia in 26 young adults was used to compared hypoxia parameters such as blood lactate, hypoxia-induced electrocardiogram signs, and the recently proposed plasma hypoxanthine concentration. At a PaO2 of 30 mm Hg, no elevation in hypoxanthine and small increase in lactate was observed. Minimal leg exercise was added to further increase hypoxic during hypoxemia. A significant increase in lactate and considerable ST-T depression in electrocardiogram indicated hypoxia, but no change in plasma hypoxanthine was found. Work-dependent hyperventilation as a main cause of lactate elevation was excluded. Blockade of hypoxanthine breakdown by allopurinol in vivo increased plasma hypoxanthine levels, but hypoxemia with or without leg exercise failed to consistently increase this level further. Elevations of blood lactate above the normal range were found at a PaO2 of 30 mm Hg and below.
在26名年轻成年人中诱导产生高原性低氧血症，以此来比较诸如血乳酸、低氧诱导心电图体征以及最近提出的血浆次黄嘌呤浓度等低氧参数。在动脉血氧分压（PaO2）为30mmHg时，未观察到次黄嘌呤升高，乳酸有小幅增加。加入最小强度的腿部运动以在低氧血症期间进一步加重低氧状态。乳酸显著增加以及心电图中出现明显的ST段压低表明存在低氧，但血浆次黄嘌呤未发现变化。排除了作为乳酸升高主要原因的与工作相关的过度通气。体内用别嘌呤醇阻断次黄嘌呤分解可增加血浆次黄嘌呤水平，但无论有无腿部运动，低氧血症均未能持续进一步升高该水平。在PaO2为30mmHg及以下时，发现血乳酸高于正常范围。
