地塞米松和异丙嗪给药对兔输卵管显微外科吻合术后粘连形成、输卵管功能及超微结构的影响。

The effect of dexamethasone and promethazine administration on adhesion formation, tubal function, and ultrastructure following microsurgical anastomosis of rabbit oviducts.

作者信息

Pfeffer W H, Wheeler J E, Tschoepe R L, Wright K H, Gizang E

出版信息

Fertil Steril. 1980 Aug;34(2):162-8. doi: 10.1016/s0015-0282(16)44901-0.

Abstract

In a controlled study, 24 rabbits underwent bilateral division and immediate microsurgical anastomosis of the oviducts. Dexamethasone and promethazine were administered to 13 rabbits in a dose and route of administration similar to those used in clinical practice. Eleven control rabbits received a saline vehicle. Morbidity and mortality were encountered only in the dexamethasone and promethazine-treated group. Dexamethasone and promethazine did not appear to influence the formation of intraluminal and peritubal adhesions, histology, ultrastructure, patency, implantation, or pregnancy rates. The presence of intraluminal adhesions, as seen by scanning electron microscopy, was associated with relatively more efficient tubal function as measured by the ability of the oviducts to convey ova to intrauterine implantation sites. Collagen accumulation in the muscularis, as demonstrated by trichrome staining, was associated with relatively decreased tubal function.

摘要

在一项对照研究中，24只兔子接受了双侧输卵管切断并立即进行显微外科吻合术。13只兔子以与临床实践中使用的剂量和给药途径相似的方式给予地塞米松和异丙嗪。11只对照兔子接受生理盐水载体。发病率和死亡率仅出现在地塞米松和异丙嗪治疗组中。地塞米松和异丙嗪似乎不影响管腔内和输卵管周围粘连的形成、组织学、超微结构、通畅性、着床或妊娠率。通过扫描电子显微镜观察到的管腔内粘连的存在，与输卵管将卵子输送到子宫内着床部位的能力所衡量的相对更有效的输卵管功能相关。经三色染色证实，肌层中胶原蛋白的积累与输卵管功能相对降低相关。